Video encoded in MPEG format, a commonly compression applied to digital video files; MPEG-2 is the most commonly used type of MPEG compression.
The MPE file extension is short for the more common .MPEG extension.
Program(s) that open mpe files
Mac: Apple QuickTime Player; Microsoft Windows Media Player; Roxio Popcorn; Other video player Windows: Apple QuickTime Player; Microsoft Windows Media Player; CyberLink PowerDirector; Other video player
Information from FileInfo.com - The File Extensions Resource.
http://www.fileinfo.com/extension/mpe